David Monroe

Jan 17, 2025 | onlinelibrary.wiley.com | Joshua N Farr |David Monroe |Elizabeth Atkinson |Mitchell N. Froemming

1 Introduction There is now substantial pre-clinical evidence, principally from mouse models, that the clearance of senescent cells ameliorates a range of age-associated comorbidities (reviewed in Chaib, Tchkonia, and Kirkland 2022).

Nov 5, 2024 | medrxiv.org | Joshua N Farr |David Monroe |Elizabeth Atkinson |Mitchell N. Froemming

The authors have declared no competing interest. NCT04313634This work was supported by National Institutes of Health grants R21 AG065868 (J.N.F. and S.K.), P01 AG062413 (S.K., D.G.M.), R01 AG076515 (S.K., D.G.M.), R01 AG086085 (S.K., D.G.M.), Hevolution HR-GRO-23-1199144-8 (S.K., D.G.M.), and R01 DK128552 (J.N.F.). The funders played no role in the conduct or analyses of this study.

Jul 2, 2024 | nature.com | Joshua N Farr |Jad G. Sfeir |Dominik Saul |Kai Yu |Tamara Tchkonia |Nathan K. LeBrasseur | +2 more

AbstractPreclinical evidence demonstrates that senescent cells accumulate with aging and that senolytics delay multiple age-related morbidities, including bone loss. Thus, we conducted a phase 2 randomized controlled trial of intermittent administration of the senolytic combination dasatinib plus quercetin (D + Q) in postmenopausal women (n = 60 participants).

Apr 3, 2024 | nywire.com | David Monroe

By: David MonroeIn the vibrant tapestry of the global art scene, a name that resonates with an increasingly fervent echo is that of Colombian artist Victor Ospina. Known for his profound ability to weave the rich cultural heritage of Colombia into the fabric of modern artistry, Ospina has not just captured the imagination of art aficionados worldwide but has also become a beacon of cultural pride for his homeland.

Jul 31, 2023 | nature.com | Madison L. Doolittle |Dominik Saul |Kevin D Pavelko |Joshua N Farr |David Monroe

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