Mitchell N. Froemming

Jan 17, 2025 | onlinelibrary.wiley.com | Joshua N Farr |David Monroe |Elizabeth Atkinson |Mitchell N. Froemming

1 Introduction There is now substantial pre-clinical evidence, principally from mouse models, that the clearance of senescent cells ameliorates a range of age-associated comorbidities (reviewed in Chaib, Tchkonia, and Kirkland 2022).

Nov 5, 2024 | medrxiv.org | Joshua N Farr |David Monroe |Elizabeth Atkinson |Mitchell N. Froemming

The authors have declared no competing interest. NCT04313634This work was supported by National Institutes of Health grants R21 AG065868 (J.N.F. and S.K.), P01 AG062413 (S.K., D.G.M.), R01 AG076515 (S.K., D.G.M.), R01 AG086085 (S.K., D.G.M.), Hevolution HR-GRO-23-1199144-8 (S.K., D.G.M.), and R01 DK128552 (J.N.F.). The funders played no role in the conduct or analyses of this study.

May 16, 2024 | jci.org | Dominik Saul |Madison L. Doolittle |Jennifer L. Rowsey |Mitchell N. Froemming

ResearchAgingBone biologyOpen Access | 10.1172/JCI179834 J Clin Invest. https://doi.org/10.1172/JCI179834. Copyright © 2024, Saul et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Feb 7, 2024 | biorxiv.org | Dominik Saul |Madison L. Doolittle |Jennifer L. Rowsey |Mitchell N. Froemming

AbstractCells expressing features of senescence, including upregulation of p21 and p16, appear transiently following tissue injury, yet the properties of these cells or how they contrast with age-induced senescent cells remains unclear. Here, we used skeletal injury as a model and identified the rapid appearance following fracture of p21+ cells expressing senescence markers, mainly as osteochondroprogenitors (OCHs) and neutrophils.