David van Heel

May 13, 2024 | nature.com | Matthew Lincoln |Christiane Gasperi |David van Heel |Sebo Withoff |Iris H. Jonkers |Leonid Padyukov | +6 more

AbstractAutoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining whether the same allele is responsible, indicating a shared underlying mechanism. Here, using a collection of 129,058 cases and controls across 6 diseases, we show that ~40% of overlapping associations are due to the same allele.