Leonid Padyukov

Sep 4, 2024 | ard.bmj.com | Kristina Lend |Jon Lampa |Leonid Padyukov |Merete Lund Hetland

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Jul 30, 2024 | ard.bmj.com | Kristina Lend |Jon Lampa |Leonid Padyukov |Merete Lund Hetland

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May 13, 2024 | nature.com | Matthew Lincoln |Christiane Gasperi |David van Heel |Sebo Withoff |Iris H. Jonkers |Leonid Padyukov | +6 more

AbstractAutoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining whether the same allele is responsible, indicating a shared underlying mechanism. Here, using a collection of 129,058 cases and controls across 6 diseases, we show that ~40% of overlapping associations are due to the same allele.

Sep 7, 2023 | nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more

Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01588-w, published online 10 August 2023. In the version of the article originally published, the middle panel in Fig. 3b was mistakenly a duplicate of the upper panel. The figure has now been corrected in the HTML and PDF versions of the article.

Aug 10, 2023 | nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more

AbstractCirculating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans).