Karl Frontzek

Sep 11, 2024 | journals.plos.org | Davide Caredio |Marusa Koderman |Karl Frontzek |Silvia Sorce |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Caredio D, Koderman M, Frontzek KJ, Sorce S, Nuvolone M, Bremer J, et al. (2024) Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle. PLoS Pathog 20(9): e1012552. https://doi.org/10.1371/journal.ppat.1012552Editor: Neil A.

May 6, 2024 | biorxiv.org | Davide Caredio |Marusa Koderman |Karl Frontzek |Silvia Sorce

AbstractIn prion diseases, aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally. Here we sequenced mRNA transcripts in skeletal muscle, spleen and blood of prion-inoculated mice at eight timepoints during disease progression. We detected gene-expression changes in all three organs, with skeletal muscle showing the most consistent alterations.

Feb 14, 2024 | nature.com | Marian Hruska-Plochan |Vera I. Wiersma |Katharina M. Betz |Elena Tantardini |Florent Laferrière |Igor Delvendahl | +11 more

AbstractHuman cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies1, which involve human-specific mechanisms2,3,4,5 that cannot be directly studied in animal models.

Nov 2, 2023 | biorxiv.org | Karl Frontzek |Silvia Sorce |Davide Caredio |Marusa Koderman

AbstractIn prion diseases, aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but can also be found in various extraneural tissues. This raises the question whether prion-specific pathologies arise also in these tissues. Here we sequenced mRNA transcripts in skeletal muscle, spleen and blood of prion-inoculated mice at eight timepoints during disease progression.