Derek W. Gilroy

Feb 19, 2024 | nature.com | Hamez Gacaferi |Jessica E. Ackerman |Peter Johnson |Ian Reekie |Moustafa Attar |Dylan Windell | +14 more

AbstractFrozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues.

Jun 13, 2023 | cell.com | George Collins |Derek W. Gilroy

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Mar 8, 2023 | biorxiv.org | Derek W. Gilroy |Ruth Irene Andrew

Contradictory Results doi: https://doi.org/10.1101/2023.03.06.530669 AbstractUsing a model of UV-killed E. coli driven dermal inflammation in healthy human volunteers we originally reported that following inflammatory resolution there was the infiltration of macrophages, which, through prostanoids including prostaglandin (PG)E2, imprints long-term tissue immunity.