Dheeraj A. Shinde

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Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer - Nature Communications

Aug 5, 2024 | nature.com | Dheeraj A. Shinde |Luca Guarrera |Marta Iozzo |Roger L. Geiger |Marco Bolis |Carlo V. Catapano | +2 more

AbstractCastration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-indifferent state in ERG fusion-positive CRPC. MAT2A is upregulated in CRPC and cooperates with ERG in promoting cell plasticity, stemness and tumorigenesis.

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