Roger L. Geiger

Dec 10, 2024 | dx.doi.org | Philip G. Altbach |Roger L. Geiger

Hostname: page-component-cc8bf7c57-ksm4s Total loading time: 0 Render date: 2024-12-10T12:25:43.749Z Has data issue: false hasContentIssue false Published online by Cambridge University Press:  10 December 2024 Keywords online educationstudent loansprivate higher educationpublic universities Type Policy Dialogue Information History of Education Quarterly , Volume 64 , Issue 4 , November 2024 , pp.

Oct 17, 2024 | nature.com | Stefania Canè |Roger L. Geiger |Vincenzo Bronte

AbstractArginase activity and arginine metabolism in immune cells have important consequences for health and disease. Their dysregulation is commonly observed in cancer, autoimmune disorders and infectious diseases. Following the initial description of a role for arginase in the dysfunction of T cells mounting an antitumour response, numerous studies have broadened our understanding of the regulation and expression of arginases and their integration with other metabolic pathways.

Sep 4, 2024 | dx.doi.org | Yun Ding |Roger L. Geiger |Giada Zoppi |Gaia Antonini

IntroductionClick to copy section linkSection link copied!Droplet-based microfluidics has dramatically reshaped the execution of high-throughput and massively parallel biological experiments over the past decade. (1−3) Innovations such as droplet digital PCR (ddPCR), (4) droplet-based single-cell RNA sequencing (DB scRNA-seq), (5,6) and fluorescence-activated droplet sorting (FADS) (7) have made impacted genetic analysis, transcriptome sequencing, and biological screening.

Aug 5, 2024 | nature.com | Dheeraj A. Shinde |Luca Guarrera |Marta Iozzo |Roger L. Geiger |Marco Bolis |Carlo V. Catapano | +2 more

AbstractCastration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-indifferent state in ERG fusion-positive CRPC. MAT2A is upregulated in CRPC and cooperates with ERG in promoting cell plasticity, stemness and tumorigenesis.

Jun 3, 2024 | nature.com | Kelly Kersten |Ori Maller |Greg A. Timblin |Mary-Kate Hayward |Bushra Samad |Alexander Muir | +2 more

AbstractTumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix accumulation, which is associated with diminished antitumor immune infiltration. Here we demonstrate that tumor-associated macrophages (TAMs) respond to the stiffened fibrotic tumor microenvironment (TME) by initiating a collagen biosynthesis program directed by transforming growth factor-β.