Marco Bolis

Aug 5, 2024 | nature.com | Dheeraj A. Shinde |Luca Guarrera |Marta Iozzo |Roger L. Geiger |Marco Bolis |Carlo V. Catapano | +2 more

AbstractCastration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-indifferent state in ERG fusion-positive CRPC. MAT2A is upregulated in CRPC and cooperates with ERG in promoting cell plasticity, stemness and tumorigenesis.

Sep 19, 2023 | pubs.aip.org | Laura Dí |Marco Bolis

Topics Computational models, Genomic techniques, Epithelial cells, BioMEMS, Cell cultures Over the last decades, the gut raised a strong interest in the health domain due to its link with the pathophysiology of other systems such as the cardiovascular and the central nervous one.1–4 Actually, gut epithelial cells, together with their resident micro-organisms (microbiota), are involved in many functions, including the modulation of the host immune system.

Jul 20, 2023 | nature.com | Marco Bolis

Correction to: Nature Communications https://doi.org/10.1038/s41467-022-29824-1, published online 21 April 2022The original version of this Article contained errors in Fig. 4C and in the Supplementary Information file. In Fig. 4C, the lower magnification image for the LNCaP Palbo + ABT263 image was a duplication of the LNCaP Docetaxel image. In Supplementary Fig. 8C, the high magnification image obscured the region of interest. In Supplementary Fig.