Diana Romero
Chief Editor at Nature
Chief Editor at Nature Reviews Clinical Oncology
Thinking aloud about scientific and medical research while I listen to random music. Chief Editor at Nat Rev Clin Onc. Views my own.
Articles
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2 months ago |
nature.com | Diana Romero
Chimeric proteins resulting from fusions involving NRG1, which encodes a growth factor from the EGF family, promote HER2–HER3 heterodimerization and subsequent oncogenic activation of cell proliferation. These fusions occur in <1% of solid tumours including non-small-cell lung cancer (NSCLC) and pancreatic adenocarcinoma (PDAC).
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2 months ago |
nature.com | Diana Romero
Patients with HER2-negative advanced-stage gastric or gastro-oesophageal junction (G/GEJ) adenocarcinomas typically receive chemotherapy with or without an anti-PD-1 antibody as first-line treatment. Now, data from the phase III COMPASSION-15 trial show that combination of the PD-1 × CTLA4 bispecific antibody cadonilimab plus chemotherapy is also efficacious in this setting.
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2 months ago |
nature.com | Diana Romero
Surgical resection is the standard of care for patients with colorectal liver metastases. Thermal ablation has emerged as an alternative management approach for small lesions (≤3 cm diameter), although how it compares with surgery is unclear because most of the available evidence is from meta-analyses of retrospective studies.
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2 months ago |
nature.com | Diana Romero
Transarterial chemoembolization (TACE) is the standard-of-care treatment for patients with intermediate-stage hepatocellular carcinoma (HCC) who are not candidates for resection, ablation or transplantation, although disease recurrence is common. Now, early data from two phase III trials demonstrate that the addition of both an immune-checkpoint inhibitor (ICI) and an anti-angiogenic agent to TACE improves patient outcomes.
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Nov 28, 2024 |
nature.com | Diana Romero
Chimeric antigen receptor (CAR) T cells have emerged as an effective treatment option for patients with relapsed and/or refractory (R/R) diffuse large B cell lymphoma (DLBCL) who are ineligible for autologous stem-cell transplantation (ASCT), although owing to manufacturing and access-related limitations many patients receive rituximab plus gemcitabine–oxaliplatin.
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Feels so right to watch this
What dads are for ❤️ This was a beautiful moment between Fred Sirieix and his daughter Andrea Spendolini-Sirieix. #Paris2024 #Olympics #BBCOlympics https://t.co/z967OK1kIp
I’m not a clinician but I guess it’s fair to say that I’m involved in medicine and completely agree. I definitely appreciate having things that never fail to cheer me up (knitting, music, super long walks…) and it greatly helps in my professional life
How to avoid burnout in medicine! You are smart, have hobbies and get good at them. For me. 1. Guitar/piano 2. Re-learning math and actually taking time to understand it. 3. Training my boarder collie to do cool stuff 4. Eating tacos, drinking beer around San Diego and Mexico
So interesting to read about @csoncol in my very favourite newspaper @elpaisinenglish (tagging English edition because I can’t find the real thing!) Thanks @darioT_ for the heads up https://t.co/QHd90Ga1p2
