Nature Reviews Clinical Oncology

1 day ago | nature.com | Annabel Tan |Adam P. Bress

AbstractExtreme temperature events related to climate change may impact blood pressure (BP). African American populations are disproportionately affected by temperature extremes due to structural inequities. We examined the association between ambient outdoor temperature and BP among participants in JHS, a cohort of African American adults residing in the tri-county area of Jackson, Mississippi.

2 days ago | nature.com | Shreya Rao |David Vidal |Keo Shaw |Danny Tobey |Shira Zilberstein |Manesh R. Patel | +7 more

As artificial intelligence (AI) becomes further embedded in healthcare, healthcare delivery organizations (HDOs) must navigate a complex regulatory landscape. Health AI Partnership (HAIP) has created 31 best practice guides to inform the development, validation, and implementation of AI products. Here, we map the most common principles found in 8 key AI regulatory frameworks to HAIP recommended best practices to provide practical insights for compliance with expanding AI regulations.

2 days ago | nature.com | Shengsong Xu |Xiao Wang |Jinyi Xu |Xingyu Lei |MengYi Wang |Xiao Yang | +3 more

To investigate the causal relationship between depression, anxiety, and myopia. The multivariable Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies (GWAS) was employed. The anxiety and depression, were used as exposures, and myopia was used as the outcome. Genetic variants associated with depression were derived using GWAS summary statistics from the FinnGen consortium database. Genetic variants associated with anxiety were derived from the Psychiatric Genomics consortium. The inverse-variance-weighted method was the main applied analytic tool and was complemented with comprehensive sensitivity analyses. A total of 21, 10 SNPs were selected as instrumental variables for depression and anxiety, respectively. Based on the IVW analysis, both depression (OR = 1.010, 95% CI = 1.002–1.018, P = 0.016) and anxiety (OR = 1.083, 95%CI = 1.022–1.149, P = 0.008) increased the risk of myopia. After adjusting in the multivariable MR, the IVW and Egger methods indicated that depression (OR = 1.004, 95%CI = 1.000–1.008, P = 0.030) or anxiety (OR = 1.004, 95%CI = 1.001–1.008, P = 0.026) was still associated with elevated risks of myopia. The current study identified a causal relationship between anxiety, depression, and an increased risk of myopia. These observations suggest that when developing strategies to control myopia, it is also important to focus on the mental health of children. Further detailed research is needed to fully understand this issue.

2 days ago | nature.com | Clara Ma |Cristina Peñasco |Laura Diaz Anadon

AbstractRoad transportation policies can drive innovation in more environmentally sustainable vehicle and fuel technologies but may have unintended consequences. To assess their impacts on technology innovation, greenhouse gas emissions, air pollution, and land use, we systematically review and analyze evidence on the outcomes of 14 road transportation policy instruments, including fuel economy and low-carbon fuel standards, biofuel and zero-emission vehicle mandates, and fuel and vehicle taxes.

3 days ago | nature.com | Jack Leeming

This article is also available as apdf version. The winners of Nature’s 2025 #ScientistAtWork photo competition are drawn entirely from fieldwork entries, taking viewers on a voyage of scientific discovery that includes the Arctic and Antarctic circles, both sides of the Pacific Ocean, and a shot from atop a Greek mountain. Nature’s careers team received more than 200 entries from researchers around the world.