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Dec 5, 2024 | 
nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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May 2, 2024 | 
gut.bmj.com | Shuai Yuan |Susanna C. Larsson |Dipender Gill |Stephen Burgess
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Nov 22, 2023 | 
lcp.com | Dipender Gill
LinkedIn
+44 (0)20 3862 0062
[email protected]
I am the Lead for Integrated Omics in the Health Analytics team at LCP.
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Oct 16, 2023 | 
nature.com | Tanmoy Roychowdhury |Derek Klarin |Michael Levin |Joshua M. Spin |Colwyn A. Headley |Noah Tsao | +44 more
AbstractAbdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical risk factors.
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Oct 13, 2023 | 
lcp.com | Dipender Gill
LinkedIn
+44 (0)20 3862 0062
[email protected]
I am the Lead for Integrated Omics in the Health Analytics team at LCP.
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Oct 11, 2023 | 
lcp.com | Dipender Gill
In this blog, Dipender Gill discusses using large-scale genetic association data to inform drug development. Drug development is inefficient. Less than 10% of drugs entering phase 1 clinical trials eventually enter clinical practice. With the median development cost of every drug that makes it to patients estimated at $1.1 billion, and this process taking approximately 10 years, such a high failure rate clearly has serious implications.
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Oct 11, 2023 | 
lcp.com | Dipender Gill
In this blog, Dipender Gill discusses using large-scale genetic association data to inform drug development. Drug development is inefficientLess than 10% of drugs entering phase 1 clinical trials eventually enter clinical practice. With the median development cost of every drug that makes it to patients estimated at $1.1 billion, and this process taking approximately 10 years, such a high failure rate clearly has serious implications.
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Mar 15, 2023 | 
inkl.com | Dipender Gill
Dr Dipender Gill, a clinical scientist at Imperial College London, worked on the new research published in the journal BMJ Medicine. He said existing studies had not been able to show a causal effect between caffeine and weight, but the new study looked at genetics, making the findings more robust. He told the PA news agency that “95% of your caffeine is metabolised by an enzyme” and that two genes called CYP1A2 and AHR affect the function and level of that enzyme.
