Divya Bezwada

Jul 2, 2024 | cell.com | Zheng Wu |Divya Bezwada |Feng Cai |Robert Harris

Highlights•ETC inhibition rewires purine metabolism•Cytosolic NAD(H) imbalance induces purine accumulation in ETC-deficient cells•HPRT1-mediated purine salvage supports NSCLC growth during ETC inhibition•Purine uptake is required to supply salvage upon ETC inhibitionSummaryMitochondria house many metabolic pathways required for homeostasis and growth.

Jun 13, 2024 | cell.com | Zheng Wu |Divya Bezwada |Feng Cai |Robert Harris

Highlights•ETC inhibition rewires purine metabolism•Cytosolic NAD(H) imbalance induces purine accumulation in ETC-deficient cells•HPRT1-mediated purine salvage supports NSCLC growth during ETC inhibition•Purine uptake is required to supply salvage upon ETC inhibitionSummaryMitochondria house many metabolic pathways required for homeostasis and growth.