Dmitry I Gabrilovich

Feb 29, 2024 | nature.com | Enyong Dai |Xin McRae Chen |Xuejun Jiang |Rui Kang |Valerian E. Kagan |Ana J. García-Sáez | +27 more

AbstractFerroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity.

Feb 24, 2024 | nature.com | Adina M. Hughes |Nathan Standifer |Scott Hoffmann |Larissa S. Carnevalli |Fernando J. Calero-Nieto |Andrew Pierce | +9 more

AbstractThe Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we show that modelling of intermittent ceralasertib treatment in mouse tumor models reveals CD8+ T-cell dependent antitumor activity, which is separate from the effects on tumor cells.

Feb 24, 2024 | nature.com | Adina M. Hughes |Nathan Standifer |Scott Hoffmann |Larissa S. Carnevalli |Fernando J. Calero-Nieto |Andrew Pierce | +9 more

AbstractThe Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we show that modelling of intermittent ceralasertib treatment in mouse tumor models reveals CD8+ T-cell dependent antitumor activity, which is separate from the effects on tumor cells.

Jun 26, 2023 | cell.com | Devon Taylor |Robert H Vonderheide |Dmitry I Gabrilovich

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Feb 6, 2023 | nature.com | Simon T. Barry |Dmitry I Gabrilovich |Owen J. Sansom

AbstractMyeloid cells are pivotal within the immunosuppressive tumour microenvironment. The accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils — termed ‘myeloid-derived suppressor cells’ — and tumour-associated macrophages is associated with poor outcome and resistance to treatments such as chemotherapy and immune checkpoint inhibitors.