Dominik Groos

Jun 20, 2024 | biorxiv.org | Dominik Groos |Anna Reuss |Peter Rupprecht |Tevye Jason Stachniak

AbstractAppropriate risk evaluation is essential for survival in complex, uncertain environments. Confronted with choosing between certain (safe) and uncertain (risky) options, animals show strong preference for either option consistently across extended time periods. How such risk preference is encoded in the brain remains elusive. A candidate region is the lateral habenula (LHb), which is prominently involved in value-guided behavior.

Mar 27, 2024 | nature.com | Nikita Vladimirov |Fabian Voigt |Sven Hildebrand |Dominik Groos |José María Mateos |Philipp Bethge | +5 more

AbstractIn 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, requiring major improvements in the capabilities of such microscopes.

Mar 22, 2024 | cell.com | Dominik Groos |Fritjof Helmchen

SummaryThe habenula is an evolutionarily highly conserved diencephalic brain region divided into two major parts, medial and lateral. Over the past two decades, studies of the lateral habenula (LHb), in particular, have identified key functions in value-guided behavior in health and disease. In this review, we focus on recent insights into LHb connectivity and its functional relevance for different types of aversive and appetitive value-guided behavior.