Fritjof Helmchen

Jan 11, 2025 | biorxiv.org | Peter Rupprecht |Wei Fan |Steve Sullivan |Fritjof Helmchen

AbstractCalcium imaging is a key method to record the spiking activity of identified and genetically targeted neurons. However, the observed calcium signals are only an indirect readout of the underlying electrophysiological events (single spikes or bursts of spikes) and require dedicated algorithms to recover the spike rate.

Jan 8, 2025 | nature.com | Fritjof Helmchen

Sep 27, 2024 | biorxiv.org | Shuting Han |Fritjof Helmchen

AbstractThe coordinated changes of neural activity during learning, from single neurons to populations of neurons and their interactions across brain areas, remain poorly understood. To reveal specific learning-related changes, we applied multi-area two-photon calcium imaging in mouse neocortex during training of a sensory discrimination task. We uncovered coordinated adaptations in primary somatosensory area S1 and the anterior (A) and rostrolateral (RL) areas of posterior parietal cortex (PPC).

Jul 22, 2024 | biorxiv.org | Peter Rupprecht |Wei Fan |Steve Sullivan |Fritjof Helmchen

AbstractCalcium imaging is a key method to record the spiking activity of identified and genetically targeted neurons. However, the observed calcium signals are only an indirect readout of the underlying electrophysiological events (single spikes or bursts of spikes) and require dedicated algorithms to recover the spike rate.

Mar 22, 2024 | cell.com | Dominik Groos |Fritjof Helmchen

SummaryThe habenula is an evolutionarily highly conserved diencephalic brain region divided into two major parts, medial and lateral. Over the past two decades, studies of the lateral habenula (LHb), in particular, have identified key functions in value-guided behavior in health and disease. In this review, we focus on recent insights into LHb connectivity and its functional relevance for different types of aversive and appetitive value-guided behavior.