Donald MacGlashan

Jan 7, 2025 | emjreviews.com | Jonathan Chen |Donald MacGlashan |Amanda Mccormack |Johns Hopkins

1. Plasmacytoid dendritic cells (pDC) are a unique subset of antigen-presenting cells known to be involved in innate immunity, cancer, and immune tolerance. 2. It is not clear why pDC express a variant of the IgE (FcεRI) receptor on their surface, or if they also exhibit a membrane-bound version of this receptor. 3. This study confirms that pDCs do express high levels of FcεRI that very tightly bind IgE on their surface, but no appreciable amount of membrane-bound IgE was detected.

Dec 2, 2023 | biorxiv.org | Jonathan Chen |Donald MacGlashan |Amanda Mccormack |John Schroeder

AbstractIntroduction Plasmacytoid dendritic cells (pDCs) are unique antigen presenting cells that may be implicated in allergic disease because they bind IgE on their surface and modulate important Th1/Th2 cytokine responses. While conducting in vitro experiments using excess omalizumab to capture IgE, we discovered that this immunoglobulin is not readily removed from pDC to the same extent observed for basophils suggesting that a portion of the IgE on pDC is membrane bound.