Jonathan Chen

Jan 7, 2025 | emjreviews.com | Jonathan Chen |Donald MacGlashan |Amanda Mccormack |Johns Hopkins

1. Plasmacytoid dendritic cells (pDC) are a unique subset of antigen-presenting cells known to be involved in innate immunity, cancer, and immune tolerance. 2. It is not clear why pDC express a variant of the IgE (FcεRI) receptor on their surface, or if they also exhibit a membrane-bound version of this receptor. 3. This study confirms that pDCs do express high levels of FcεRI that very tightly bind IgE on their surface, but no appreciable amount of membrane-bound IgE was detected.

Dec 3, 2024 | mondaq.com | Brian Kolenda |Jonathan Chen

Canada's federal structure means national class actions naturally raise potential constitutional questions. Those questions become potentially more thorny where a class action is pursued not on behalf of individuals across multiple provinces and territories, but instead provincial and territorial governments themselves.

Nov 29, 2024 | hawaiiathletics.com | Jonathan Chen

LOGAN TAYLOR arrived in Manoa after spending a year at El Camino College in 2019. Taylor had a quiet first two years, joining the roster as a reserve defensive back and special teams contributor in 2020, and missing most of 2021 with an injury. “Man, those first few years, they were rough for me. But one of my favorite quotes is, ‘prosperity is a mercy. It's a great mercy. But adversity is a greater mercy, if it leads you to Christ,” Taylor said.

Nov 26, 2024 | cell.com | Kathryn R. Bowles |Chiara Pedicone |Derian A Pugh |Laura-Maria Oja |Brian Fulton-Howard |Sarah Weitzman | +5 more

CRISPR/Cas9 genome editingHuman iPSCs were edited using the pSpCas9(BB)-2A-GFP (PX458) construct backbone (Addgene #48138) described in Ran et al 201382. For WT correction of S305 mutation lines, specific guide RNAs (gRNAs) were designed against the mutant allele using the Zhang lab design tool (crispr.mit.edu), and guides with the highest quality scores and more than 3bp mismatches with other genomic loci were selected.

Nov 24, 2024 | raptorsrepublic.com | Jonathan Chen

Canada defeats Mexico in a hard-fought 83-73 victory, extending their win streak to 4 games in 2025 AmeriCup Qualifier play. Before the final game of Window 2 even kicked off, the SMNT made two interesting adjustments. After looking a bit disjointed in the first matchup against the Dominican Republic, which saw Canada turn the ball over 14 times (an AmeriCup Qualifier high), HC Nate Mitchell decided to bring Kadre Gray into the fold, replacing Josip Vrankic.