Dong Wei

Nov 29, 2024 | pubs.acs.org | Yufeng Liu |Guiyuan Zhang |Dong Wei |Hao Zhang

Oct 4, 2024 | translational-medicine.biomedcentral.com | Yameng Zhao |Siyu Li |Dong Wei |Ye Tao |Yange Wang |Lulu Sha

Retinal neurovascular unit (NVU) is a multi-cellular structure that consists of the functional coupling between neural tissue and vascular system. Disrupted NVU will result in the occurrence of retinal and choroidal vascular diseases, which are characterized by the development of neovascularization, increased vascular permeability, and inflammation. This pathological entity mainly includes neovascular age-related macular degeneration (neovascular-AMD), diabetic retinopathy (DR) retinal vein occlusion (RVO), and retinopathy of prematurity (ROP). Emerging evidences suggest that the angopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Ang/Tie) signaling pathway is essential for the development of retinal and choroidal vascular. Tie receptors and their downstream pathways play a key role in modulating the vascular development, vascular stability, remodeling and angiogenesis. Angiopoietin 1 (Ang1) is a natural agonist of Tie2 receptor, which can promote vascular stability. On the other hand, angiopoietin 2 (Ang2) is an antagonist of Tie2 receptor that causes vascular instability. Currently, agents targeting the Ang/Tie signaling pathway have been used to inhibit neovascularization and vascular leakage in neovascular-AMD and DR animal models. Particularly, the AKB-9778 and Faricimab have shown promising efficacy in improving visual acuity in patients with neovascular-AMD and DR. These experimental and clinical evidences suggest that activation of Ang/Tie signaling pathway can inhibit the vascular permeability, neovascularization, thereby maintaining the normal function and structure of NVU. This review seeks to introduce the versatile functions and elucidate the modulatory mechanisms of Ang/Tie signaling pathway. Recent pharmacologic therapies targeting this pathway are also elaborated and summarized. Further translation of these findings may afford a new therapeutic strategy from bench to bedside.

Aug 7, 2024 | mdpi.com | Yue Ma |Hui Li |Yufeng Li |Dong Wei

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Jan 17, 2024 | aging-us.com | Dong Wei |Ying Liu |Ying Yuan |Yishuai Li

Background: The cGAS-STING pathway emerges as a pivotal innate immune pathway with the potential to profoundly influence all facets of tumor initiation and progression. The prognostic significance and immunological role of cGAS-STING pathway-related genes (CRGs) in individuals diagnosed with bladder cancer (BLCA) have not yet been fully elucidated. Methods: Performed unsupervised cluster analysis to identify distinct clusters.

Jan 17, 2024 | aging-us.com | Dong Wei |Ying Liu |Ying Yuan |Yishuai Li

Research Paper Volume 16, Issue 2 pp 1516—1535 1 Department of Urology, Hebei General Hospital, Shijiazhuang 050000, China 2 Department of Neurology, Xingtai Third Hospital, Xingtai 054000, China 3 Department of Thoracic Surgery, Hebei Chest Hospital, Shijiazhuang 050000, China 4 Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China 5 Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000,...