Siyu Li

1 month ago | tandfonline.com | Xinyuan Zhang |Luyao Chen |Wenjun Ma |Siyu Li

?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. ABSTRACTRooted in ancient architectural wisdom, Sunken Courtyard Cave dwellings exemplify advanced green strategies for climate-responsive design.

Oct 24, 2024 | ceramics.onlinelibrary.wiley.com | Chang Li |Siyu Li |Pengfei Liu |Ping Tang

CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES 1, . Computational simulation of liquid-fuelled HVOF thermal spraying. Surf Coat Technol. 2009; 204(5): 676–684. 2, , , . Computational fluid dynamic modeling of gas flow characteristics in a high-velocity oxy-fuel thermal spray system. J Therm Spray Technol. 2001; 10(3): 461–469. 3. The science and engineering of thermal spray coatings. Chichester, UK: John Wiley & Sons Ltd; 2008. 4, , .

Oct 4, 2024 | translational-medicine.biomedcentral.com | Yameng Zhao |Siyu Li |Dong Wei |Ye Tao |Yange Wang |Lulu Sha

Retinal neurovascular unit (NVU) is a multi-cellular structure that consists of the functional coupling between neural tissue and vascular system. Disrupted NVU will result in the occurrence of retinal and choroidal vascular diseases, which are characterized by the development of neovascularization, increased vascular permeability, and inflammation. This pathological entity mainly includes neovascular age-related macular degeneration (neovascular-AMD), diabetic retinopathy (DR) retinal vein occlusion (RVO), and retinopathy of prematurity (ROP). Emerging evidences suggest that the angopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Ang/Tie) signaling pathway is essential for the development of retinal and choroidal vascular. Tie receptors and their downstream pathways play a key role in modulating the vascular development, vascular stability, remodeling and angiogenesis. Angiopoietin 1 (Ang1) is a natural agonist of Tie2 receptor, which can promote vascular stability. On the other hand, angiopoietin 2 (Ang2) is an antagonist of Tie2 receptor that causes vascular instability. Currently, agents targeting the Ang/Tie signaling pathway have been used to inhibit neovascularization and vascular leakage in neovascular-AMD and DR animal models. Particularly, the AKB-9778 and Faricimab have shown promising efficacy in improving visual acuity in patients with neovascular-AMD and DR. These experimental and clinical evidences suggest that activation of Ang/Tie signaling pathway can inhibit the vascular permeability, neovascularization, thereby maintaining the normal function and structure of NVU. This review seeks to introduce the versatile functions and elucidate the modulatory mechanisms of Ang/Tie signaling pathway. Recent pharmacologic therapies targeting this pathway are also elaborated and summarized. Further translation of these findings may afford a new therapeutic strategy from bench to bedside.

Sep 23, 2024 | seekingalpha.com | Siyu Li

Sep. 23, 2024 1:52 AM ET, SummaryDollar Tree's core business has performed comparably to Walmart since 2023. Its 50% drop presents an attractive opportunity. Dollar Stores face macro headwinds, but they expose no durable or structural risks to the Dollar Stores. Dollar Tree's strategic review and initiatives under Dreiling's leadership could unlock its trapped value and presents further upside.

Sep 16, 2024 | onlinelibrary.wiley.com | Qin Chen |Siyu Li |Weifeng Zhao |Changsheng Zhao

1 Introduction Skin wound healing is a highly intricate and dynamic process that needs to activate and coordinate a large number of intracellular and intercellular signals to restore tissue integrity, preserve wound stability, and culminate in the formation of scar tissue.[1] Unfortunately, various factors such as surgery procedures, trauma, burns, or other skin injuries inevitably result in the development of skin scars.