Donghui Wei

Nov 25, 2024 | nature.com | Xiao Xiao |Donghui Wei

AbstractEnantioenriched unsymmetrical vicinal diamines are important basic structural motifs. While catalytic asymmetric intermolecular 1,2-diamination of carbon–carbon double bonds represents the most straightforward approach for preparing enantioenriched vicinal-diamine-containing heterocycles, these reactions are often limited to the installation of undifferentiated amino functionalities through metal catalysis and/or the use of stoichiometric amounts of oxidants.

Sep 2, 2024 | pubs.rsc.org | Qianqian Wang |Yan Qiao |Donghui Wei

Unraveling proton-coupled electron transfer in cofactor-free oxidases- and oxygenases-catalyzed oxygen activation: a theoretical view Oxygen plays a crucial role in the metabolism of non-anaerobic organisms. However, understanding the detailed process of how triplet oxygen participates in the enzymatic oxidation of organic compounds involved in life processes is still lacked.

Jul 25, 2024 | dx.doi.org | Peng Zhao |Donghui Wei |Di Wu |Lili Wang

May 29, 2024 | nature.com | Xiao Xiao |Donghui Wei

AbstractChirality constitutes an inherent attribute of nature. The catalytic asymmetric synthesis of molecules with central, axial, and helical chirality is a topic of intense interest and is becoming a mature field of research. However, due to the difficulty in synthesis and the lack of a prototype, less attention has been given to planar chirality arising from the destruction of symmetry on a single planar ring.

Aug 25, 2023 | nature.com | Xiao Xiao |Donghui Wei

AbstractThe catalytic asymmetric dearomatization (CADA) reaction has proved to be a powerful protocol for rapid assembly of valuable three-dimensional cyclic compounds from readily available planar aromatics. In contrast to the well-studied indoles and naphthols, phenols have been considered challenging substrates for intermolecular CADA reactions due to the combination of strong aromaticity and potential regioselectivity issue over the multiple nucleophilic sites (O, C2 as well as C4).