Qianqian Wang

Jan 7, 2025 | biorxiv.org | Han Wang |YuXuan Luo |Qianqian Wang |Sandeep Artham

AbstractTargeting the estrogen receptor (ER or ERα) through competitive antagonists, receptor downregulators, or estrogen synthesis inhibition remains the primary therapeutic strategy for luminal breast cancer. We have identified a novel mechanism of ER inhibition by targeting the critical interface between its DNA-binding domain (DBD) and ligand-binding domain (LBD). We demonstrate that mitoxantrone (MTO), a topoisomerase II inhibitor, binds at this previously unexplored DBD-LBD interface.

Dec 25, 2024 | journalofinfection.com | Huili Zhou |Xindie Ren |Yujing Li |Caihong Ji |Xin Wei |Xiaohan Huang | +10 more

Letter to the EditorArticles in Press106385Open access 1Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China 2Department of Emergency Intensive Care Unit, The Fifth Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, China 3Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China 4MOE Key Laboratory of Biosystems Hon& Protection, and Zhejiang...

Nov 28, 2024 | mdpi.com | Qianqian Wang |Siyuan Yang |Lingyun Huang |Shuo Liu

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Oct 29, 2024 | scijournals.onlinelibrary.wiley.com | Wei Zhang |Yong Chen |Qianqian Wang |jun chen

BACKGROUND Intelligent identification and precise plucking are the keys to intelligent tea harvesting robots, which are currently of increasing significance. Aiming at plucking tender leaves for high-quality green tea production, in this study, a tender leaf identification algorithm and a mechanically perceptible plucking finger have been proposed.

Sep 2, 2024 | pubs.rsc.org | Qianqian Wang |Yan Qiao |Donghui Wei

Unraveling proton-coupled electron transfer in cofactor-free oxidases- and oxygenases-catalyzed oxygen activation: a theoretical view Oxygen plays a crucial role in the metabolism of non-anaerobic organisms. However, understanding the detailed process of how triplet oxygen participates in the enzymatic oxidation of organic compounds involved in life processes is still lacked.