Doron Merkler

Dec 23, 2024 | cell.com | Anna Lena Kastner |Anna-Friederike Marx |Mirela Dimitrova |Tiago Abreu-Mota |Yusuf I. Ertuna |Weldy V. Bonilla | +6 more

Keywordsadeno-associated viral vectordepletion antibodygenetically engineered mouse modelslymphocyte subsetB cellsCD8 T cellschronic viral infectionlymphocytic choriomeningitis virusdepletion-AAVIntroductionOn repeated occasions over the past decades, technological advancements have redefined the way biomedical research is conducted.

May 30, 2023 | nature.com | Thomas Gruber |Nicolas Page |Nicolas Blanchard |Markus Schwaninger |Mirjam Schenk |Doron Merkler | +2 more

AbstractBlood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells are found in MS lesions, and antigen (Ag) presentation at the BBB has been proposed to promote CD8+ T cell entry into the CNS. Here, we show that brain endothelial cells process and cross-present Ag, leading to effector CD8+ T cell differentiation.