
Mirjam Schenk
Articles
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May 30, 2023 |
nature.com | Thomas Gruber |Nicolas Page |Nicolas Blanchard |Markus Schwaninger |Mirjam Schenk |Doron Merkler | +2 more
AbstractBlood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells are found in MS lesions, and antigen (Ag) presentation at the BBB has been proposed to promote CD8+ T cell entry into the CNS. Here, we show that brain endothelial cells process and cross-present Ag, leading to effector CD8+ T cell differentiation.
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