Douglas V. Guzior

Jan 8, 2025 | nature.com | Bingsen Zhang |Jeffrey Letourneau |Yousi Fu |Douglas V. Guzior |Robert Quinn |Chun-Jun Guo | +3 more

AbstractMetabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development1, metabolism2,3,4, immune responses5,6,7 and cognitive function8. However, to what extent host responses balance the physiological effects of microbiota-derived metabolites remains unclear9,10.

Nov 13, 2024 | nature.com | Hao Wu |Douglas V. Guzior |Christian Martin |Robert Quinn

AbstractPopulation studies have shown that the infant’s microbiome and metabolome undergo significant changes in early childhood. However, no previous study has investigated how diverse these changes are across subjects and whether the subject-specific dynamics of some microbes correlate with the over-time dynamics of specific metabolites.

May 10, 2023 | nature.com | Robert Quinn |Christian Martin |Douglas V. Guzior

Most of human microbiome research has focused on analysing faecal samples, which represent the final stop of the digestive journey. Two recent articles use a novel sampling approach to capture luminal content at different points during digestion and reveal that the analysis of faecal samples tells only a fraction of the story.