E. Shyong Tai

Sep 30, 2023 | nature.com | Yunkyeong Lee |Han Sun |Daphne Su-Lyn Gardner |E. Shyong Tai |Anna L Gloyn |Hwee Hui Lau | +1 more

AbstractThe coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta cell formation but its role on human beta cell development and/or function is unknown.

Mar 29, 2023 | nature.com | Yu Xu |Scott Ritchie |Maik Pietzner |Loïc Lannelongue |Samuel A. Lambert |Sebastian May-Wilson | +17 more

AbstractThe use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics1.