Ecco Staller

May 14, 2024 | nature.com | Ecco Staller |Loïc Carrique |Haitian Fan |Jeremy Keown |Carol M. Sheppard |Wendy Barclay | +1 more

AbstractAvian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian cells is hindered by species-specific variation in acidic nuclear phosphoprotein 32 (ANP32) proteins, which are essential for viral RNA genome replication. Adaptive mutations enable the IAV RNA polymerase (FluPolA) to surmount this barrier.