Edward F. Chang

Nov 15, 2024 | nature.com | John Andrews |Kateryna Voitiuk |Alex Spaeth |Albert Wang |Jessica L. Sevetson |Kevin C. Donohue | +8 more

AbstractSeizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the pathologic circuits of epilepsy could allow for control of the disease. Optogenetics has been effective at stopping seizure-like activity in non-human disease models by increasing inhibitory tone or decreasing excitation, although this effect has not been shown in human brain tissue.

Jun 19, 2024 | nature.com | Edward F. Chang |Mercedes F. Paredes

AbstractAdvances in large-scale single-unit human neurophysiology, single-cell RNA sequencing, spatial transcriptomics and long-term ex vivo tissue culture of surgically resected human brain tissue have provided an unprecedented opportunity to study human neuroscience.

Feb 6, 2024 | biologicalpsychiatryjournal.com | Prasad Shirvalkar |Philip A Starr |Edward F. Chang

Chronic pain affects 1 in 4 adults and is often refractory to treatment. Deep brain stimulation (DBS) for pain has been studied for over 70 years, but an objective biomarker that can guide therapy is still lacking. Previous research was limited by focusing on experimental pain tasks in healthy individuals, constraining clinical application. This study aimed to identify real-world brain biomarkers of chronic pain to personalize DBS.

May 3, 2023 | nature.com | Abrar Choudhury |Alexander Aabedi |Galina Popova |Benjamin Lipkin |Annette M. Molinaro |Humsa Venkatesh | +5 more

Patients, samples, consent and ethics approvalEach participant in the study was recruited from a prospective registry of adults aged 18–85 with newly diagnosed frontal, temporal and parietal IDH-WT high-grade gliomas with detailed language assessments and baseline MEG recordings. Inclusionary criteria included the following: native English speaking, aged 18–85 years, and no previous history of psychiatric illness, neurological illness, or drug or alcohol abuse.