Alex Spaeth

1 month ago | biorxiv.org | Matthew Elliott |John Andrews |Jinghui Geng |Alex Spaeth

AbstractHow seizures begin at the level of microscopic neuronal circuits remains unknown. Advancements in high-density CMOS-based microelectrode arrays can be harnessed to study neuronal network activity with unprecedented spatial and temporal resolution. We use high-density electrophysiology recordings to probe the network activity of human hippocampal brain slices from six patients with mesial temporal lobe epilepsy.

Jan 7, 2025 | biorxiv.org | Alex Spaeth |Mattia Chini |Sebastián Hernandez |Sebastián Hernandez |Gregory A Kaurala

AbstractNeuronal firing sequences are thought to be the basic building blocks of neural coding and information broadcasting within the brain. However, when sequences emerge during neurodevelopment remains unknown. We demonstrate that structured firing sequences are present in spontaneous activity of human and murine brain organoids and ex vivo neonatal brain slices from the murine somatosensory cortex.

Nov 15, 2024 | nature.com | John Andrews |Kateryna Voitiuk |Alex Spaeth |Albert Wang |Jessica L. Sevetson |Kevin C. Donohue | +8 more

AbstractSeizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the pathologic circuits of epilepsy could allow for control of the disease. Optogenetics has been effective at stopping seizure-like activity in non-human disease models by increasing inhibitory tone or decreasing excitation, although this effect has not been shown in human brain tissue.

Feb 6, 2024 | biorxiv.org | Alex Spaeth |David Haussler |Mircea Teodorescu

AbstractDue to the complexity of neuronal networks and the nonlinear dynamics of individual neurons, it is challenging to develop a systems-level model which is accurate enough to be useful yet tractable enough to apply. Mean-field models which extrapolate from single-neuron descriptions to large-scale models can be derived from the neuron's transfer function, which gives its firing rate as a function of its synaptic input.

Oct 27, 2023 | zenodo.org | Alex Spaeth |David Parks |Pierre V. Baudin |Matthew Elliott |Rob Currie |Kateryna Voitiuk | +7 more

Published October 27, 2023 | Version v0.1.0 Software Open What's ChangedAdded concatenate method, fixed fatal error in subset(), and fixed issue with neuron_attributes being empty when reading from phys data by @MissValeska in https://github.com/braingeneers/braingeneerspy/pull/7Fix, moved experiment to metadata instead of NeuronAttributes by @ashsrobbins in https://github.com/braingeneers/braingeneerspy/pull/11The most basic possible test for read_phy_files().