Elaine C. Wirrell

Jul 4, 2024 | onlinelibrary.wiley.com | Elaine C. Wirrell |Lieven Lagae |Ingrid E. Scheffer |J. Helen Cross

Fenfluramine (FFA) is an antiseizure medication (ASM) used in the treatment of seizures associated with Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS). FFA is initiated at 0.2 mg/kg/day but speed of titration may depend on age, weight, and concomitant medications. FFA is generally well-tolerated and associated with a low risk of clinically relevant drug–drug interactions, which are often observed with polypharmacy.

Mar 15, 2024 | emjreviews.com | J. Helen Cross |Elaine C. Wirrell

IntroductionDS, which has a prevalence of 1.5−6.5/ 100,000,1-5 is predominantly due to variants in the gene SCN1A affecting the sodium channel.6 Onset is usually in the first year of life, with prolonged and recurrent seizures. Further seizure types emerge, including myoclonic, absence, and focal seizures with impaired awareness, which persist into adulthood. Prior to seizure onset, development is usually typical, or with only minor delay.

May 17, 2023 | onlinelibrary.wiley.com | Alejandra Vasquez |Elaine C. Wirrell

No abstract is available for this article. Open Research Not required. The full text of this article hosted at iucr.org is unavailable due to technical difficulties.