Elisabeth Paul

Oct 15, 2024 | onlinelibrary.wiley.com | Elisabeth Paul |Garrett Brown |David Bell |Valéry Ridde

It is no longer a matter of obeying a principle of order (excluding disorder), of clarity (excluding obscurity), of distinction (excluding adherences, participations and communications), of disjunction (excluding subject, antinomy, complexity), that is to say a principle which ties science to logical simplification. On the contrary, starting from a principle of complexity, it is a matter of linking what was disjointed.

Oct 20, 2023 | nature.com | Elisabeth Paul |Karin Wåhlén |Liina Haring

AbstractImmune cells and cytokines are largely recognized as significant factors in the pathophysiology of neuropsychiatric disorders. The possible role of other blood cells such as leukocytes in events of acute psychosis is in contrast only emerging. To study blood-born markers in acute psychosis we here evaluated plasma proteins in drug-naive first-episode psychosis (FEP) patients and healthy controls using a multiplex proximity extension assay technique.

May 19, 2023 | nature.com | Elisabeth Paul |Markus Heilig |Helen S. Mayberg

AbstractBiological assay and imaging techniques have made visible a great deal of the machinery of mental illness. Over fifty years of investigation of mood disorders using these technologies has identified several biological regularities in these disorders. Here we present a narrative connecting genetic, cytokine, neurotransmitter, and neural-systems-level findings in major depressive disorder (MDD).

Apr 11, 2023 | nature.com | Andrea J. Capusan |Elisabeth Paul |Bijar Ghafouri |Irene Perini

AbstractChildhood maltreatment (CM) is a risk factor for substance use disorders (SUD) in adulthood. Understanding the mechanisms by which people are susceptible or resilient to developing SUD after exposure to CM is important for improving intervention. This case-control study investigated the impact of prospectively assessed CM on biomarkers of endocannabinoid function and emotion regulation in relation to the susceptibility or resilience to developing SUD.