Elisenda Alsina-Sanchis

Sep 25, 2023 | nature.com | Leonie Uhl |Benedetto Daniele Giaimo |Tobias Friedrich |Elisenda Alsina-Sanchis |David Sprinzak |Carolin Mogler | +5 more

AbstractCachexia is a major cause of morbidity and mortality in individuals with cancer and is characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white adipose tissue (WAT) remodeling, which often precedes weight loss, are impaired lipid storage, inflammation and eventually fibrosis. Tissue wasting occurs in response to tumor-secreted factors.

Apr 24, 2023 | nature.com | Elisa Donato |Elisa Espinet |Elisenda Alsina-Sanchis |Elena Fernández-Florido |Andreas Trumpp |Carolin Mogler | +3 more

AbstractPancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely understood. Here, we show that the presence of hyaluronan and proteoglycan link protein-1 (HAPLN1) in the extracellular matrix enhances tumor cell plasticity and PDAC metastasis.