Carolin Mogler

Jul 10, 2024 | nature.com | Sainitin Donakonda |Jitao Zhang |Hannah Wintersteller |Martin Feuerherd |Juliane Siebourg-Polster |Carolin Mogler | +24 more

AbstractChronic hepatitis B virus (HBV) infection affects 300 million patients worldwide1,2, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes3,4,5,6,7. Here we demonstrate that a liver immune rheostat renders virus-specific CD8 T cells refractory to activation and leads to their loss of effector functions.

Sep 25, 2023 | nature.com | Leonie Uhl |Benedetto Daniele Giaimo |Tobias Friedrich |Elisenda Alsina-Sanchis |David Sprinzak |Carolin Mogler | +5 more

AbstractCachexia is a major cause of morbidity and mortality in individuals with cancer and is characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white adipose tissue (WAT) remodeling, which often precedes weight loss, are impaired lipid storage, inflammation and eventually fibrosis. Tissue wasting occurs in response to tumor-secreted factors.

Jul 12, 2023 | mdpi.com | Miriam Dibos |Carolin Mogler |Johanna Dumoulin |Silke Wunderlich

Open AccessCase ReportbyMiriam Dibos 1, Johanna Dumoulin 1, Carolin Mogler 2, Silke Wunderlich 3, Maximilian Reichert 1, Sebastian Rasch 1, Roland M. Schmid 1, Marc Ringelhan 1, Ursula Ehmer 1 and Tobias Lahmer 1,* 1Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str.

Apr 24, 2023 | nature.com | Elisa Donato |Elisa Espinet |Elisenda Alsina-Sanchis |Elena Fernández-Florido |Andreas Trumpp |Carolin Mogler | +3 more

AbstractPancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely understood. Here, we show that the presence of hyaluronan and proteoglycan link protein-1 (HAPLN1) in the extracellular matrix enhances tumor cell plasticity and PDAC metastasis.