Emil M Pedersen

Apr 10, 2024 | agderposten.no | Emil M Pedersen

Sep 9, 2023 | nature.com | Emil M Pedersen |David M. Hougaard |Thomas Werge |Anders D. Børglum |Katherine L. Musliner |Andrea Ganna | +3 more

AbstractProportional hazards models have been proposed to analyse time-to-event phenotypes in genome-wide association studies (GWAS). However, little is known about the ability of proportional hazards models to identify genetic associations under different generative models and when ascertainment is present. Here we propose the age-dependent liability threshold (ADuLT) model as an alternative to a Cox regression based GWAS, here represented by SPACox.