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Feb 26, 2024 | 
nature.com | Clara Albiñana |Zhihong Zhu |Nis Borbye-Lorenzen |Kristin Skogstrand |Naomi R. Wray |Joana A. Revez | +7 more
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-36392-5, published online 15 February 2023The original version of this article contained an error in the second paragraph of the ‘Assay of DBP concentration’ section of the ‘Methods’, which incorrectly read ‘The lower and upper detection limits for DBP were 2.07 and 79.8 mg/L respectively’. The correct version states ‘2.07 µg/L’ in place of ‘2.07’. This has been corrected in both the PDF and HTML versions of the article.
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Dec 7, 2023 | 
nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more
AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).
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Dec 7, 2023 | nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more
AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).
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Nov 29, 2023 | 
nature.com | Clare Palmer |Morten Krebs |Vivek Appadurai |Esben Agerbo |Anders D. Børglum |David M. Hougaard | +7 more
AbstractAttention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in long-term outcomes and clinical presentations. The genetic contributions to such heterogeneity are not well understood. Here we show several genetic links to clinical heterogeneity in ADHD in a case-only study of 14,084 diagnosed individuals. First, we identify one genome-wide significant locus by comparing cases with ADHD and autism spectrum disorder (ASD) to cases with ADHD but not ASD.
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Nov 20, 2023 | 
nature.com | Daniel F Levey |Marco Galimberti |Joseph D. Deak |Dora Koller |Emma Johnson |Mahantesh Biradar | +12 more
AbstractAs recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.
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Nov 12, 2023 | 
nature.com | Clara Albiñana |Bjarni J Vilhjálmsson |Thomas Werge |David M. Hougaard |Anders D. Børglum |Preben mortensen | +1 more
AbstractIt remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark.
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Oct 5, 2023 | 
nature.com | Robin Beaumont |Christopher Flatley |Marc Vaudel |JING CHEN |Gunn-Helen Moen |Line Skotte | +52 more
AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.
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Sep 9, 2023 | 
nature.com | Emil M Pedersen |David M. Hougaard |Thomas Werge |Anders D. Børglum |Katherine L. Musliner |Andrea Ganna | +3 more
AbstractProportional hazards models have been proposed to analyse time-to-event phenotypes in genome-wide association studies (GWAS). However, little is known about the ability of proportional hazards models to identify genetic associations under different generative models and when ascertainment is present. Here we propose the age-dependent liability threshold (ADuLT) model as an alternative to a Cox regression based GWAS, here represented by SPACox.
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Aug 5, 2023 | 
nature.com | Clara Albiñana |Hugues Aschard |Cynthia Bulik |Jakob Grove |David M. Hougaard |Thomas Werge | +5 more
AbstractThe predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effectively increased by using genetically correlated phenotypes. We propose a framework to generate multi-PGS from thousands of publicly available genome-wide association studies (GWAS) with no need to individually select the most relevant ones.
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Jul 18, 2023 | 
nature.com | Thomas D. Als |Jakob Grove |Georgios Voloudakis |Karen Therrien |Joonas Naamanka |Daniel F Levey | +15 more
AbstractDepression is a common psychiatric disorder and a leading cause of disability worldwide. Here we conducted a genome-wide association study meta-analysis of six datasets, including >1.3 million individuals (371,184 with depression) and identified 243 risk loci. Overall, 64 loci were new, including genes encoding glutamate and GABA receptors, which are targets for antidepressant drugs.
