-
Dec 9, 2024 | 
nature.com | Georgios Voloudakis |Karen Therrien |Simone Tomasi |Veera M. Rajagopal |Ditte Demontis |John F. Fullard | +3 more
AbstractPolygenic scores (PGS) enable the exploration of pleiotropic effects and genomic dissection of complex traits. Here, in 421,889 individuals with European ancestry from the Million Veteran Program and UK Biobank, we examine how PGS of 17 neuropsychiatric traits are related to membership in 22 broad professional categories.
-
Jul 16, 2024 | 
nature.com | Jinjie Duan |Daniel F Levey |G. Bragi Walters |Emma Johnson |Arpana Agrawal |Joel Gelernter | +2 more
AbstractCannabis use disorder (CUD) and cannabis use (CU) are prevalent conditions co-occurring with attention-deficit hyperactivity disorder (ADHD). Here we report results from a cross-disorder genome-wide association study of ADHD and CUD or CU. We identified 36 concordant genome-wide significant loci for ADHD–CUD and ten loci for ADHD–CU. DRD2 was identified as an ADHD–CUD risk gene.
-
Jun 16, 2024 | 
nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more
AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.
-
Feb 26, 2024 | 
nature.com | Clara Albiñana |Zhihong Zhu |Nis Borbye-Lorenzen |Kristin Skogstrand |Naomi R. Wray |Joana A. Revez | +7 more
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-36392-5, published online 15 February 2023The original version of this article contained an error in the second paragraph of the ‘Assay of DBP concentration’ section of the ‘Methods’, which incorrectly read ‘The lower and upper detection limits for DBP were 2.07 and 79.8 mg/L respectively’. The correct version states ‘2.07 µg/L’ in place of ‘2.07’. This has been corrected in both the PDF and HTML versions of the article.
-
Dec 7, 2023 | 
nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more
AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).
-
Dec 7, 2023 | nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more
AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).
-
Nov 29, 2023 | 
nature.com | Clare Palmer |Morten Krebs |Vivek Appadurai |Esben Agerbo |Anders D. Børglum |David M. Hougaard | +7 more
AbstractAttention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in long-term outcomes and clinical presentations. The genetic contributions to such heterogeneity are not well understood. Here we show several genetic links to clinical heterogeneity in ADHD in a case-only study of 14,084 diagnosed individuals. First, we identify one genome-wide significant locus by comparing cases with ADHD and autism spectrum disorder (ASD) to cases with ADHD but not ASD.
-
Nov 20, 2023 | 
nature.com | Daniel F Levey |Marco Galimberti |Joseph D. Deak |Dora Koller |Emma Johnson |Mahantesh Biradar | +12 more
AbstractAs recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.
-
Nov 12, 2023 | 
nature.com | Clara Albiñana |Bjarni J Vilhjálmsson |Thomas Werge |David M. Hougaard |Anders D. Børglum |Preben mortensen | +1 more
AbstractIt remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark.
-
Sep 9, 2023 | 
nature.com | Emil M Pedersen |David M. Hougaard |Thomas Werge |Anders D. Børglum |Katherine L. Musliner |Andrea Ganna | +3 more
AbstractProportional hazards models have been proposed to analyse time-to-event phenotypes in genome-wide association studies (GWAS). However, little is known about the ability of proportional hazards models to identify genetic associations under different generative models and when ascertainment is present. Here we propose the age-dependent liability threshold (ADuLT) model as an alternative to a Cox regression based GWAS, here represented by SPACox.
