Emily E. Hartwell

Jul 22, 2024 | nature.com | Emily E. Hartwell |Joel Gelernter |Henry R Kranzler

AbstractCo-occurring psychiatric, medical, and substance use disorders (SUDs) are common, but the complex pathways leading to such comorbidities are poorly understood. A greater understanding of genetic influences on this phenomenon could inform precision medicine efforts. We used the Yale-Penn dataset, a cross-sectional sample enriched for individuals with SUDs, to examine pleiotropic effects of genetic liability for psychiatric and somatic traits.

May 7, 2024 | nature.com | Zeal Jinwala |Emily E. Hartwell |Mirko Pavicic |Kyle Sullivan |Ke Xu |Daniel Jacobson | +5 more

Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-02839-5, published online 1 March 2024In the version of the article initially published, the pipeline for the cross-ancestry meta-analysis did not accurately code some SNPs such that they were not combined despite being the same polymorphism. To fix this, we correctly annotated the rsIDs for the summary statistics from each ancestry and meta-analyzed them based on the unique rsID for each polymorphism.

Mar 1, 2024 | nature.com | Zeal Jinwala |Emily E. Hartwell |Mirko Pavicic |Kyle Sullivan |Ke Xu |Daniel Jacobson | +5 more

AbstractChronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids had a central role in precipitating the opioid crisis.