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Sep 18, 2024 | 
onlinelibrary.wiley.com | Gordon Barr |Heath D. Schmidt |Ashish P. Thakrar |Henry R Kranzler
1 INTRODUCTION Opioid misuse and dependence continue to be a public health crisis throughout the world.1 Opioid use disorder (OUD) remains a serious public health problem, affects over 35 million people worldwide, and more than 2.1 million in the United States alone. OUD mortality and morbidity have worsened with the spread of high-potency synthetic opioids such as fentanyl in the unregulated drug supply.
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Jul 22, 2024 | 
nature.com | Emily E. Hartwell |Joel Gelernter |Henry R Kranzler
AbstractCo-occurring psychiatric, medical, and substance use disorders (SUDs) are common, but the complex pathways leading to such comorbidities are poorly understood. A greater understanding of genetic influences on this phenomenon could inform precision medicine efforts. We used the Yale-Penn dataset, a cross-sectional sample enriched for individuals with SUDs, to examine pleiotropic effects of genetic liability for psychiatric and somatic traits.
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Apr 16, 2024 | 
nature.com | Sylvanus Toikumo |Benjamin Pham |Travis T. Mallard |John J Meredith |Laura Vilar-Ribó |Emma Johnson | +14 more
AbstractTobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factors influence smoking behaviours and although strides have been made using genome-wide association studies to identify risk variants, most variants identified have been for nicotine consumption, rather than TUD.
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Apr 8, 2024 | 
medrxiv.org | Lu Wang |Henry R Kranzler |Joel Gelernter |Hang Zhou
J.G. is paid for his editorial work on the journal Complex Psychiatry. J.G. and H.R.K. hold US patent 10,900,082 titled: "Genotype-guided dosing of opioid agonists," issued January 26, 2021.
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Dec 7, 2023 | 
nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more
AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).
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Dec 7, 2023 | nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more
AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).
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Nov 20, 2023 | 
nature.com | Daniel F Levey |Marco Galimberti |Joseph D. Deak |Dora Koller |Emma Johnson |Mahantesh Biradar | +12 more
AbstractAs recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.
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Aug 1, 2023 | 
ajp.psychiatryonline.org | Henry R Kranzler
AbstractAlcohol is regularly consumed throughout most of the world, including by nearly half the U.S. population age 12 or older. Heavy drinking, which is also common, contributes to multiple adverse medical, psychiatric, and social outcomes and more than 140,000 deaths annually in the United States. It is the major risk factor for alcohol use disorder (AUD), whose current U.S. prevalence is 11%.
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May 5, 2023 | 
nature.com | Hang Zhou |Rachel L. Kember |Hongyu Zhao |Joel Gelernter |Henry R Kranzler
Study samples and phenotypesThe MVP recruited veteran volunteers and collected data from them using questionnaires, access to their electronic medical records (EMRs), and genomic analysis of blood samples. The Institutional Review Board (IRB) of the Veterans Affairs Central Office and site-specific IRBs approved the MVP study.
