Emily Jacobs

Oct 7, 2024 | elifesciences.org | Claudia Barth |Emily Jacobs |Bonnie Lee |Lars T. Westlye

Ovarian hormones such as estrogens and progesterone fluctuate across the female lifespan with natural declines occurring at menopause, typically between the ages 45 and 55. The cessation of ovarian function during the menopausal transition has been linked to an array of neural changes 1, including a decline in brain glucose metabolism 2, reductions in gray matter (GM) and white matter (WM) volume 3–6, and increased amyloid-beta deposition 7 as well as WM lesions 8.