-
Oct 30, 2024 | 
biorxiv.org | Dani Beck |Lars T. Westlye |Christian K. Tamnes |Linn RS Lindseth
AbstractPre- and perinatal factors such as maternal pregnancy and child birth complications affect child brain development, emphasizing the importance of early life exposures. While most previous studies have focused on a few variables in isolation, here, we investigated associations between a broad range of pregnancy- and birth-related variables and multivariate cortical brain MRI features. Our sample consisted of 8,396 children aged 8.9 to 11.1 years from the ABCD Study.
-
Oct 7, 2024 | 
elifesciences.org | Claudia Barth |Emily Jacobs |Bonnie Lee |Lars T. Westlye
Ovarian hormones such as estrogens and progesterone fluctuate across the female lifespan with natural declines occurring at menopause, typically between the ages 45 and 55. The cessation of ovarian function during the menopausal transition has been linked to an array of neural changes 1, including a decline in brain glucose metabolism 2, reductions in gray matter (GM) and white matter (WM) volume 3–6, and increased amyloid-beta deposition 7 as well as WM lesions 8.
-
Oct 1, 2024 | 
nature.com | Shahram Bahrami |Kaja Nordengen |Olav B. Smeland |Nadine Staples Parker |Pravesh Parekh |Torbjørn Elvsåshagen | +4 more
AbstractThe basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans.
-
Aug 21, 2024 | 
nature.com | Milin Kim |Esten Leonardsen |Geir Selbæk |Nils Eiel Steen |Olav B. Smeland |Geneviève Richard | +4 more
AbstractThe cerebellum is linked to motor coordination, cognitive and affective processing, in addition to a wide range of clinical illnesses. To enable robust quantification of individual cerebellar anatomy relative to population norms, we mapped the normative development and aging of the cerebellum across the lifespan using brain scans of >54,000 participants. We estimated normative models at voxel-wise spatial precision, enabling integration with cerebellar atlases.
-
Jun 16, 2024 | 
biorxiv.org | Max Korbmacher |Lars T. Westlye |Ivan Maximov
AbstractThe influence of FreeSurfer version-dependent variability in reconstructed cortical features on brain age predictions is average small when varying training and test splits from the same data. FreeSurfer version differences can lead to some variability in brain age dependent on the choice of algorithm and individual differences in brain morphometry, highlighting the advantage of repeated random train-test splitting.
-
May 1, 2024 | 
flipboard.com | Esten Leonardsen |Karin Persson |Nicola K. Dinsdale |James Roe |Didac Vidal-Piñeiro |Øystein Sørensen | +11 more
Science21 hours agoOptical illusion reveals key brain rule that governs consciousnessLive Science - By Emily Cooke • 21hA study of mice starts to unravel how the brain gets tricked by this kind of optical illusion, and it gives clues about how visual perception …fitness articles1 day agoWant A Healthier Heart, Gut, & Brain Over 40?
-
May 1, 2024 | 
nature.com | Esten Leonardsen |Didac Vidal-Piñeiro |Øystein Sørensen |Tobias Kaufmann |Eric C Westman |Geir Selbæk | +2 more
AbstractDeep learning approaches for clinical predictions based on magnetic resonance imaging data have shown great promise as a translational technology for diagnosis and prognosis in neurological disorders, but its clinical impact has been limited. This is partially attributed to the opaqueness of deep learning models, causing insufficient understanding of what underlies their decisions.
-
Apr 29, 2024 | 00932-6/abstract?rss=yes&sz=64)
biologicalpsychiatryjournal.com | Megan Campbell |Alina Sartorius |Lars T. Westlye |Natalia Tesli
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.
-
Apr 29, 2024 | 00945-4/fulltext?rss=yes&sz=64)
biologicalpsychiatryjournal.com | Anders Thorsen |Florence Boehmisch |Andreas Dahl |Lars T. Westlye
BackgroundEarly life adversity (ELA; childhood trauma, abuse and neglect) impacts the development of brain macrostructure, including cortical thickness and (sub)cortical volumes as measured using MRI. However, less is known about gray matter microstructure, including myelination, with preliminary animal and post-mortem human studies suggesting less myelination in adulthood after ELA. Here, we present the first longitudinal study of ELA and brain microstructure in adolescence.
-
Apr 16, 2024 | 
nature.com | Francesco Bettella |Claudia Barth |Nils Eiel Steen |Emanuel Schwarz |Dan Stein |Ole A. Andreassen | +2 more
AbstractOxytocin is a neuropeptide associated with both psychological and somatic processes like parturition and social bonding. Although oxytocin homologs have been identified in many species, the evolutionary timeline of the entire oxytocin signaling gene pathway has yet to be described.
