Emma ACERBO

Sep 20, 2024 | biorxiv.org | Henry Michael Skelton |Nathaniel Hyman |Alejandra Fernandez |Alejandra Fernández |Emma ACERBO

AbstractExercise has been extensively studied in Parkinson's Disease, with a particular focus on the potential for neuroprotection that has been demonstrated in animal models. While this preclinical work has provided insight into the underlying molecular mechanisms, it has not addressed the neurophysiological changes during exercise. Here, first, we tested for neuroprotective effects of adaptive wheel exercise in the 6-hydroxydopamine mouse model of Parkinson's disease.

Mar 26, 2024 | medrxiv.org | Daniel L. Drane |Emma ACERBO |Anna Rodgers |Nigel P. Pedersen

Medtronic, Inc. has contributed research funding to Emory University during the past that was not directly related to this project. Medtronic, Inc. develops products related to the research described in the paper. Drs. Gross and Willie serve as consultants to Medtronic, Inc. and receive compensation for these services.

Jan 14, 2024 | biorxiv.org | Emma ACERBO |Boris Botzanowski |Damián Dellavale |Matthew Stern

AbstractTemporal Interference (TI) is an emerging method to non-invasively stimulate deep brain structures. This innovative technique is increasingly recognized for its potential applications in the treatment of various neurological disorders, including epilepsy, depression, and Alzheimer's disease. However, several drawbacks to the TI method exist that we aim to improve upon.

Dec 22, 2023 | brainstimjrnl.com | Charlotte Luff |Emma ACERBO |Aix-Marseille Université |Patrycja Dzialecka

Highlights•PWM-TI is an effective non-invasive brain stimulation strategy. •PWM-TI stimulates neural activity with similar efficiency to conventional TI. •PWM-TI mechanism involves the low-pass filter property of the neuronal membrane.

Sep 6, 2023 | biorxiv.org | Boris Botzanowski |Emma ACERBO |Sarah L Kearsley |Melanie Steiner

AbstractTemporal interference (TI) stimulation is a unique method of non-invasive deep brain stimulation (DBS) using transcutaneous electrodes which allows the targeting and stimulation of deeper brain structures while avoiding unwanted stimulation of shallower cortical structures. The DBS property of TI has been previously demonstrated, however, the problem of decoupling stimulation focality from stimulation intensity has not been addressed.