Nathaniel Hyman

Sep 20, 2024 | biorxiv.org | Henry Michael Skelton |Nathaniel Hyman |Alejandra Fernandez |Alejandra Fernández |Emma ACERBO

AbstractExercise has been extensively studied in Parkinson's Disease, with a particular focus on the potential for neuroprotection that has been demonstrated in animal models. While this preclinical work has provided insight into the underlying molecular mechanisms, it has not addressed the neurophysiological changes during exercise. Here, first, we tested for neuroprotective effects of adaptive wheel exercise in the 6-hydroxydopamine mouse model of Parkinson's disease.