Encarnacion Torres

Aug 1, 2024 | jci.org | Ali Abbara |Waljit S. Dhillo |Encarnacion Torres |Manuel Tena-Sempere

AbstractKisspeptin is an essential neuropeptide sitting at the apex of the hypothalamo-pituitary-gonadal (HPG) endocrine axis to regulate gonadotropin-releasing hormone (GnRH) neurons and downstream reproductive hormones. Kisspeptin neurons integrate feedback from sex steroids facilitating regulation of the menstrual cycle and mediate the effects of metabolic stressors on the reproductive axis.