Manuel Tena-Sempere

Aug 1, 2024 | jci.org | Ali Abbara |Waljit S. Dhillo |Encarnacion Torres |Manuel Tena-Sempere

AbstractKisspeptin is an essential neuropeptide sitting at the apex of the hypothalamo-pituitary-gonadal (HPG) endocrine axis to regulate gonadotropin-releasing hormone (GnRH) neurons and downstream reproductive hormones. Kisspeptin neurons integrate feedback from sex steroids facilitating regulation of the menstrual cycle and mediate the effects of metabolic stressors on the reproductive axis.

Jul 6, 2024 | cell.com | Miguel Lopez |Miguel López |Santiago de Compostela |Carlos Diéguez |Manuel Tena-Sempere

Abstract Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals – such as leptin, ghrelin, thyroid hormones, or estradiol – and to modulate the central control of puberty. In this forum article we discuss recent evidence suggesting that specific ceramide species and neuronal populations are involved in these effects.

Apr 29, 2024 | thelancet.com | Manuel Tena-Sempere

With the increase in obesity prevalence worldwide, considerable efforts have been made to investigate the molecular and neurohormonal mechanisms of bodyweight control, as a means to identify novel therapeutic targets.

Apr 29, 2024 | thelancet.com | Manuel Tena-Sempere

With the increase in obesity prevalence worldwide, considerable efforts have been made to investigate the molecular and neurohormonal mechanisms of bodyweight control, as a means to identify novel therapeutic targets.