Michael Gregory

May 5, 2024 | nature.com | Michael Gregory

AbstractUnderstanding neurogenetic mechanisms underlying neuropsychiatric disorders such as schizophrenia and autism is complicated by their inherent clinical and genetic heterogeneity. Williams syndrome (WS), a rare neurodevelopmental condition in which both the genetic alteration (hemideletion of ~ twenty-six 7q11.23 genes) and the cognitive/behavioral profile are well-defined, offers an invaluable opportunity to delineate gene-brain-behavior relationships.

Apr 30, 2024 | nature.com | Leonardo Sportelli |Daniel Eisenberg |Enrico D’Ambrosio |Michael Gregory |Thomas Hyde |Joel E. Kleinman | +6 more

AbstractThe polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals.

Apr 29, 2024 | biologicalpsychiatryjournal.com | Anne K. Ilsley |Daniel Eisenberg |Michael Gregory |Nathan Mann

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Sep 30, 2023 | nature.com | Daniel Eisenberg |Michael Gregory |Joseph C. Masdeu |Timothy E Behrens |Angela M. Ianni |Sara M. Constantino

AbstractForaging behavior requires weighing costs of time to decide when to leave one reward patch to search for another. Computational and animal studies suggest that striatal dopamine is key to this process; however, the specific role of dopamine in foraging behavior in humans is not well characterized.