Leonardo Sportelli

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Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo - Nature Communications

Apr 30, 2024 | nature.com | Leonardo Sportelli |Daniel Eisenberg |Enrico D’Ambrosio |Michael Gregory |Thomas Hyde |Joel E. Kleinman | +6 more

AbstractThe polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals.
Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function.

Sep 21, 2023 | biorxiv.org | Daniel Eisenberg |Roberta Passiatore |Leonardo Sportelli |Enrico D'Ambrosio

AbstractSchizophrenia (SCZ) is characterized by a polygenic risk architecture implicating diverse molecular pathways important for synaptic function. However, how polygenic risk funnels through these pathways to translate into syndromic illness is unanswered.

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