Enzo Lezin

Jan 11, 2025 | biorxiv.org | Sébastien Besseau |Mickael Durand |Duchesse-Lacours Zamar |Enzo Lezin

AbstractMonoterpene indole alkaloids (MIAs) constitute a vast group of plant natural products synthesized within the Gentianales order. MIAs possess outstanding pharmacological properties that explain their wide use in the treatment of human diseases. These biological activities result from the complex structure of MIAs that originate from intricated biosynthetic pathways involving several enzyme families and notably cytochrome P450s.

Oct 20, 2024 | onlinelibrary.wiley.com | Enzo Lezin |Mickael Durand |Caroline Williams |Thomas Perrot

INTRODUCTION Monoterpene indole alkaloids (MIAs) are a class of natural products mainly synthesized in plant species from the Gentianales order and in Cornales to a lower extent (St-Pierre et al., 2013). Besides encompassing complex chemistries, MIAs exhibit potent biological activities explaining their roles in the adaptation of plants to their environment and defense against bioagressors (Dugé De Bernonville et al., 2017).

Jul 30, 2024 | biorxiv.org | Mickael Durand |Caroline Williams |Thomas Perrot |Enzo Lezin

AbstractPlant specialized metabolism represents an inexhaustible source of active molecules, some of which have been used in human health for decades. Among these, monoterpene indole alkaloids (MIAs) include a wide range of valuable compounds with anticancer, antihypertensive, or neuroactive properties. This is particularly the case for the pachysiphine derivatives which show interesting antitumor and anti-alzheimer activities but accumulate at very low levels in several Tabernaemontana species.