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Oct 20, 2024 | 
onlinelibrary.wiley.com | Enzo Lezin |Mickael Durand |Caroline Williams |Thomas Perrot
INTRODUCTION Monoterpene indole alkaloids (MIAs) are a class of natural products mainly synthesized in plant species from the Gentianales order and in Cornales to a lower extent (St-Pierre et al., 2013). Besides encompassing complex chemistries, MIAs exhibit potent biological activities explaining their roles in the adaptation of plants to their environment and defense against bioagressors (Dugé De Bernonville et al., 2017).
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Jul 30, 2024 | 
biorxiv.org | Mickael Durand |Caroline Williams |Thomas Perrot |Enzo Lezin
AbstractPlant specialized metabolism represents an inexhaustible source of active molecules, some of which have been used in human health for decades. Among these, monoterpene indole alkaloids (MIAs) include a wide range of valuable compounds with anticancer, antihypertensive, or neuroactive properties. This is particularly the case for the pachysiphine derivatives which show interesting antitumor and anti-alzheimer activities but accumulate at very low levels in several Tabernaemontana species.
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Nov 28, 2023 | 
pnas.org | Thomas Perrot |Adrien Rusch |Sabrina Gaba |Vincent Bretagnolle
SignificanceFerroicities like magnetism and polarity are fundamental physical properties of matter and vital for electronic devices. Here, a missed branch of ferroicities, coined as alterferroicity, is theoretically revealed and implemented in two-dimensional materials. Different from its sister multiferroicity which requires the coexistence of multiple ferroics, alterferroicity exhibits multiple but noncoexisting ferroic orders.
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Nov 28, 2023 | 
pnas.org | Thomas Perrot |Adrien Rusch |Sabrina Gaba |Taylor A. B
Dominant heterocyclic composition of dissolved organic nitrogen in the ocean: A new paradigm for cycling and persistenceEdited by Donald Canfield, Syddansk Universitet, Odense M., Denmark; received April 10, 2023; accepted October 24, 2023SignificanceMarine dissolved organic nitrogen (DON) represents one of the largest pools of reduced nitrogen in the ocean.
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Nov 28, 2023 | 
pnas.org | Nahum Sonenberg |Thomas Perrot |Adrien Rusch |Mir Munir A
mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memoryVijendra Sharma [email protected], Mauricio M. Oliveira, Rapita Sood, +16 , Abdessattar Khlaifia, Danning Lou https://orcid.org/0000-0001-9191-5721, Mehdi Hooshmandi, Tzu-Yu Hung, Niaz Mahmood, Maya Reeves, David Ho-Tieng, Noah Cohen, Po-chieh Cheng, Mir Munir A. Rahim, Masha Prager-Khoutorsky, Randal J.
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Nov 28, 2023 | 
pnas.org | Chang Woo |Thomas Perrot |Adrien Rusch |Sabrina Gaba
M. R. Wasielewski et al., Exploiting chemistry and molecular systems for quantum information science. Nat. Rev. Chem. 4, 490–504 (2020). M. Atzori, R. Sessoli, The second quantum revolution: Role and challenges of molecular chemistry. J. Am. Chem. Soc. 141, 11339–11352 (2019). G. Z. Zhu et al., Functionalizing aromatic compounds with optical cycling centres. Nat. Chem. 14, 995–999 (2022). S. L. Bayliss et al., Enhancing spin coherence in optically addressable molecular qubits through host–matrix control. Phys. Rev.
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Nov 28, 2023 | 
pnas.org | de Wijn |Thomas Perrot |Paul Lourdu |Rahmani Mashhour
Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFXLainey J. Williamson https://orcid.org/0000-0003-3575-5078, Marina Galchenkova https://orcid.org/0000-0003-0978-5695, Hannah L. Best https://orcid.org/0000-0002-2612-2749, +33 , Richard J.
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Nov 27, 2023 | 
pnas.org | Xiaoliang Sunney Xie |Xiaoliang Sunney |Thomas Perrot |Adrien Rusch
Single-cell bisulfite-free 5mC and 5hmC sequencing with high sensitivity and scalability Yunlong Cao https://orcid.org/0000-0001-5918-1078, Yali Bai https://orcid.org/0000-0003-2220-9692, Tianjiao Yuan https://orcid.org/0000-0002-7949-4490, +8 , Liyang Song, Yu Fan, Liuhao Ren https://orcid.org/0009-0002-0763-4834, Weiliang Song, Jiahui Peng, Ran An, Qingqing Gu, Yinghui Zheng, and Xiaoliang Sunney Xie [email protected] -8Authors Info & Affiliations Contributed by Xiaoliang Sunney...
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Nov 27, 2023 | 
pnas.org | Thomas Perrot |Adrien Rusch |Sabrina Gaba |Vincent Bretagnolle
Social stress induces autoimmune responses against the brainYusuke Shimo https://orcid.org/0000-0003-4856-0579, Flurin Cathomas, Hsiao-yun Lin, +7 , Kenny L. Chan, Lyonna F. Parise, Long Li, Carmen Ferrer-Pérez https://orcid.org/0000-0002-8890-4869, Samer Muhareb https://orcid.org/0009-0007-8401-4010, Sara Costi https://orcid.org/0000-0002-7937-8596, James W. Murrough https://orcid.org/0000-0001-6286-1242, and Scott J.
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Nov 27, 2023 | 
pnas.org | Thomas Perrot |Adrien Rusch |Vincent Bretagnolle |Sabrina Gaba
R. F. Bell, C. Eccleston, E. A. Kalso, Ketamine as an adjuvant to opioids for cancer pain. Cochrane Database Syst. Rev. 11, CD003351 (2012). S. H. Ng, M. L. Tse, H. W. Ng, F. L. Lau, Emergency department presentation of ketamine abusers in Hong Kong: A review of 233 cases. Hong Kong Med. J. 16, 6–11 (2010). W. K. Tang et al., Psychiatric morbidity in ketamine users attending counselling and youth outreach services. Subst. Abus 36, 67–74 (2015). J. H.
