Sébastien Besseau

Jan 11, 2025 | biorxiv.org | Sébastien Besseau |Mickael Durand |Duchesse-Lacours Zamar |Enzo Lezin

AbstractMonoterpene indole alkaloids (MIAs) constitute a vast group of plant natural products synthesized within the Gentianales order. MIAs possess outstanding pharmacological properties that explain their wide use in the treatment of human diseases. These biological activities result from the complex structure of MIAs that originate from intricated biosynthetic pathways involving several enzyme families and notably cytochrome P450s.

Nov 23, 2023 | nature.com | Inês Carqueijeiro |Hans Jansen |Thu-Thuy T. Dang |Sarah O’Connor |Michael Jensen |Sébastien Besseau | +2 more

AbstractMonoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized metabolites mainly produced in Gentianales to cope with environmental challenges. Due to their pharmacological properties, the biosynthetic modalities of several MIA types have been elucidated but not that of the yohimbanes.