Eric F Lock

Sep 10, 2024 | respiratory-research.biomedcentral.com | Sarah Samorodnitsky |Eric F Lock |Ken Kunisaki |Alison Morris |Janice M. Leung |Subina Mehta | +6 more

PLWH who had undergone bronchoscopy were selected from the Pittsburgh and Vancouver Lung HIV Cohorts [15, 16]. This consisted of individuals (n = 25) with OLD as defined as the ratio of forced expiratory volume in 1-s/forced vital capacity (FEV1/FVC) < lower limit of normal.

Jul 20, 2023 | respiratory-research.biomedcentral.com | Arianne K. Baldomero |David Macdonald |Adam Kaplan |Eric F Lock |Michael Cho |Russell Bowler | +3 more

In this cohort of current and former smokers, we confirmed previous findings of ours and others that higher bilirubin levels are associated with fewer acute respiratory events, but our novel analysis of a genetic determinant of higher bilirubin was not associated with acute respiratory event risk.

Mar 1, 2023 | openres.ersjournals.com | Sarah Samorodnitsky |Eric F Lock |Alison Morris |Janice M. Leung

DiscussionWe found that the BALF proteome in persons living with HIV distinguishes those with obstructive lung disease from those without obstructive lung disease. However, we did not identify any pathways composed of proteins that were differentially expressed among individuals with high FEV1 % pred and those with low FEV1 % pred. We did identify an endotype driven by both proteomic and metabolomic BALF molecular contributors, but not plasma metabolites.